Abstract: A joint anti-jamming algorithm in space-domain of main and side lobe for main lobe shape preserving is proposed in this paper. Firstly, the DOA estimation algorithm based on feature space (ES-DOA) is applied to estimate the number and angle of interference sources. Then, the blocking matrix preprocess- symmetric extension of steering vectors joint (BMP-SESV) method proposed in this paper is applied to restore the array freedom while eliminating the main lobe interference. Finally, the minimum power beamforming algorithm QIC-LCMP with quadratic inequality linear constraint is adopted to further suppress sidelobe interference and improve beamforming robustness. The simulation results show that the proposed joint spatial anti-interference algorithm can effectively solve the problems of main lobe broadening, beam direction deviation, and sidelobe level rise, and has good anti-interference performance against main and sidelobe interference.