Abstract:  In this paper, the spatial and temporal distribution information of ground deformation in the main urban area of Wuxi City, Jiangsu Province, is obtained by time-series InSAR technique using the Sentinel-1A satellite image data from 2019 to 2021 and analysed by subregion in conjunction with the groundwater level data for the mechanism of subsidence and uplift. Meanwhile, based on the data of each driving factor that may lead to subsidence in the study area and the geodetic detector model, the spatio-temporal evolution pattern of ground subsidence and the influencing factors in the urban area of Wuxi are quantitatively analysed. The results of the study show that: (1) the main urban area of Wuxi City shows unevenly distributed uplift and subsidence, with the subsidence area concentrated in the north and south, the uplift area concentrated in the northwest and southeast, and the rate of deformation ranging from -22 to 20 mm/a, while the other areas tend to be stable. (2) In the differentiation and factor detection, groundwater level is the dominant factor affecting subsidence. (3) In the interaction detection, the synergistic effect of groundwater level and building density showed the highest explanatory power, and the interaction explanation of each driving factor was enhanced.